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| Date | Opponent | Location | Time(Eastern)/Result | TV |
| Aug. 30 | Texas | Columbus | W, 14-7 | Fox |
| Sept. 6 | Grambling | Columbus | W, 70-10 | BTN |
| Sept. 13 | Ohio | Columbus | W, 37-9 | Peacock |
| Sept. 20 | Off | N/A | N/A | N/A |
| Sept. 27 | at Washington | Seattle, Wash. | W, 24-6 | CBS |
| Oct. 4 | Minnesota | Columbus | W, 42-3 | NBC |
| Oct. 11 | at Illinois | Champaign, Ill. | W, 34-16 | Fox |
| Oct. 18 | at Wisconsin | Madison, Wis. | W, 34-0 | CBS |
| Oct. 25 | Off | N/A | N/A | N/A |
| Nov. 1 | Penn State | Columbus | W, 38-14 | Fox |
| Nov. 8 | at Purdue | West Lafayette, Ind. | W, 34-10 | BTN |
| Nov. 15 | UCLA | Columbus | 7:30 p.m. | NBC |
| Nov. 22 | Rutgers | Columbus | Noon/3:30/4 p.m.
| TBA |
| Nov. 29 | at Michigan | Ann Arbor, Mich. | Noon | Fox |
| Date | Opponent | Location | Time/Result | TV |
| Sept. 5 | Ball State | Columbus | TBA | TBA |
| Sept. 12 | at Texas | Austin, Texas | TBA | TBA |
| Sept. 19 | Kent State | Columbus | TBA | TBA |
| TBA | Illinois | Columbus | TBA | TBA |
| TBA | Maryland | Columbus | TBA | TBA |
| TBA | Michigan | Columbus | TBA | TBA |
| TBA | Northwestern | Columbus | TBA | TBA |
| TBA | Oregon | Columbus | TBA | TBA |
| TBA | at Indiana | Bloomington, Ind. | TBA | TBA |
| TBA | at Iowa | Iowa City, Iowa | TBA | TBA |
| TBA | at Nebraska | Lincoln, Neb. | TBA | TBA |
| TBA | at USC | Los Angeles, Calif. | TBA | TBA |
| Date | Opponent | Location | Time/Result | TV |
| Sept. 4 | Bowling Green | Columbus | TBA | TBA |
| Sept. 11 | New Hampshire | Columbus | TBA | TBA |
| Sept. 18 | Alabama | Columbus | TBA | TBA |
| TBA | Michigan State | Columbus | TBA | TBA |
| TBA | Purdue | Columbus | TBA | TBA |
| TBA | Nebraska | Columbus | TBA | TBA |
| TBA | USC | Columbus | TBA | TBA |
| TBA | at Michigan | Ann Arbor, Mich. | TBA | TBA |
| TBA | at Minnesota | Minneapolis, Minn. | TBA | TBA |
| TBA | at Northwestern | Evanston, Ill. | TBA | TBA |
| TBA | at Oregon | Eugene, Ore. | TBA | TBA |
| TBA | at Rutgers | Piscataway, N.J. | TBA | TBA |
| Date | Opponent | Location | Time/Result | TV |
| Sept. 2 | Buffalo | Columbus | TBA | TBA |
| Sept. 9 | at Alabama | Tuscaloosa, Ala. | TBA | TBA |
| Sept. 16 | Northern Illinois | Columbus | TBA | TBA |
| TBA | Michigan | Columbus | TBA | TBA |
| TBA | Minnesota | Columbus | TBA | TBA |
| TBA | Rutgers | Columbus | TBA | TBA |
| TBA | Washington | Columbus | TBA | TBA |
| TBA | Wisconsin | Columbus | TBA | TBA |
| TBA | at Illinois | Champaign, Ill. | TBA | TBA |
| TBA | at Maryland | College Park, Md. | TBA | TBA |
| TBA | at Penn State | State College, Pa. | TBA | TBA |
| TBA | at UCLA | Pasadena, Calif. | TBA | TBA |
| Date | Opponent | Location | Time/Result | TV |
| Sept. 14 | at Georgia | Athens, GA | TBA | TBA |
| Date | Opponent | Location | Time/Result | TV |
| Aug. 30 | Georgia | Columbus | TBA | TBA |
| Date | Opponent | Location | Time/Result | TV |
| Sept. 11 | at Oregon | Eugene, OR | TBA | TBA |
| Date | Opponent | Location | Time/Result | TV |
| Sept. 10 | Oregon | Columbus | TBA | TBA |
| Date | Opponent | Location | Time/Result | TV |
| Sept. 15 | Boston College | Columbus | TBA | TBA |
| Date | Opponent | Location | Time/Result | TV |
| Sept. 13 | at Boston College | Chestnut Hill, MA | TBA | TBA |
