| Oct. 30 | vs. Cedarville (Exhibition) | Columbus | 7 p.m./95-52 (W) | BTN+ |
| Nov. 6 | vs. Cincinnati | Columbus | 8:30 p.m./64-56 W | FS1 |
| Nov. 10 | vs. UMass-Lowell | Columbus | 4 p.m./76-56 W | ESPNU |
| Nov. 13 | vs. Villanova | Columbus | 7 p.m./76-51 W | FS1 |
| Nov. 18 | vs. Stetson | Columbus | 8:30 p.m./86-51 W | BTN |
| Nov. 22 | vs. Purdue Fort-Wayne | Columbus | 7 p.m./85-46 W | BTN+ |
| Nov. 25 | vs. Kent State | Columbus (St. John Arena) | 6:30 p.m./71-52 W | BTN |
| Nov. 29 | vs. Morgan State | Columbus | 9 p.m./90-57 W | BTN |
| Dec. 4 | at North Carolina | Chapel Hill, N.C. | 9:30 p.m./74-49 W | ESPN |
| Dec. 7 | vs. Penn State | Columbus | 12 p.m./106-74 W | BTN |
| Dec. 15 | at Minnesota | Minneapolis | 6:30 p.m./84-71 L | BTN |
| Dec. 17 | vs. Southeast Missouri State | Columbus | 7 p.m./80-48 W | BTN |
| Dec. 21 | vs. Kentucky | Las Vegas | 5:15 p.m./71-65 W | CBS |
| Dec. 29 | vs. West Virginia | Cleveland | 12 p.m./67-59 L | FS1 |
| Jan. 3 | vs. Wisconsin | Columbus | 7 p.m./61-57 L | FS1 |
| Jan. 7 | at Maryland | College Park, Md. | 7 p.m./67-55 L | ESPN/ESPN2 |
| Jan. 11 | at Indiana | Bloomington, Ind. | 12 p.m./66-54 L | FOX |
| Jan. 14 | vs. Nebraska | Columbus | 6:30 p.m./80-68 W | FS1 |
| Jan. 18 | at Penn State | University Park, Pa. | 12 p.m./90-76 L | ESPN/ESPN2/ESPNU |
| Jan. 23 | vs. Minnesota | Columbus | 6:30 p.m./62-59 L | FS1 |
| Jan. 26 | at Northwestern | Evanston, Ill. | 6:30 p.m./71-59 W | BTN |
| Feb. 1 | vs. Indiana | Columbus | 12 p.m./68-59 W | ESPN/ESPN2 |
| Feb. 4 | at Michigan | Ann Arbor, Mich. | 7 p.m./61-58 W | ESPN/ESPN2 |
| Feb. 9 | at Wisconsin | Madison, Wis. | 1 p.m./70-57 L | CBS |
| Feb. 12 | vs. Rutgers | Columbus | 7 p.m./68-52 | BTN |
| Feb. 15 | Purdue | Columbus | 12 p.m./72-66 | FOX |
| Feb. 20 | at Iowa | Iowa City | 7 p.m. | ESPN/ESPN2 |
| Feb. 23 | vs. Maryland | Columbus | 4 p.m. | CBS |
| Feb. 27 | at Nebraska | Lincoln, Neb. | 9 p.m. | ESPN/ESPN2 |
| March 1 | vs. Michigan | Columbus | 4 p.m. | CBS |
| March 5 | vs. Illinois | Columbus | 7 p.m. | ESPN/ESPN2 |
| March 8 | at Michigan State | East Lansing, Mich. | 4:30 p.m. | CBS |
| March 11-15 | Big Ten Tournament | Indianapolis | TBA | TBA |
